|
KMID : 0613820090190070886
|
|
Journal of Life Science
2009 Volume.19 No. 7 p.886 ~ p.891
|
|
|
A Comprehensive Analysis of a Large Panel of Cancer/Testis (CT) Antigens in Korea Breast Cancer
|
|
Bae Jae-Ho
Kim Min-Ju
Park Hae-Rim
Song Myung-Ha
Kim Jee-Yeon
Lee Chang-Hun
Kwak Hi-Suk
Lee Sang-Yull
|
|
|
Abstract
|
|
|
|
Cancer/testis (CT) antigens are immunogenic in cancer patients, exhibit highly tissue-restricted expression, and are considered promising target molecules for cancer vaccines. We investigated the expression of 13 CT genes in 29 Korean patients with primary breast carcinoma. The most frequently expressed CT genes were MAGE-3 (66%) and MAGE-1 (57%), followed by LAGE-1 (55%), NY-SAR-35 (49%), MAGE-4 (41%), NY-ESO-1 (38%), CT-7 (24%) and SSX-4 (24%), whereas SSX-1, SSX-2, MAGE-10 and NY-TLU-57 were found to be expressed significantly less often (3-7%) and SCP-1 not all. Expression of at least one antigen was observed in 28 breast cancer samples. Immunohistochemistry was performed for NY-ESO-1 and MAGE-3 protein expression in breast tumor samples. NY-ESO-1 and MAGE-3 proteins were expressed in 11 of 29 (38%) and 12 of 29 (41%) breast tumors. Our results suggest that CT antigens may be potential candidates for polyvalent immunotherapy in Korean breast cancer patients.
|
|
|
KEYWORD
|
|
|
Breast cancer, cancer/testis(CT) antigen, cancer immunotherapy, NY-ESO-1, MAGE-3
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|